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Biochemistry & Polymer Chemistry

Cofactor

A non-protein chemical component required for an enzyme to function.

Unit Dimensionless

In depth

Cofactors may be inorganic metal ions or organic coenzymes, and they may be loosely bound or permanently attached as prosthetic groups. Metal ions typically stabilise negative charge in the transition state or participate directly in redox chemistry.

Examples in the real world

Zinc in carbonic anhydrase, magnesium in every kinase, and iron within the haem of cytochromes.