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Biochemistry & Polymer Chemistry

Tertiary Structure

The complete three-dimensional folded shape of a single polypeptide chain.

Unit Dimensionless

In depth

Tertiary structure is held by side chain interactions — hydrophobic clustering, hydrogen bonds, ionic bridges and covalent disulfide links. The dominant driving force is the burial of non-polar side chains away from water, which creates the hydrophobic core.

Examples in the real world

The globular fold of myoglobin creating a pocket that holds its haem group precisely.