Home Wikituition Browse all terms Categories
Random term
Biochemistry & Polymer Chemistry

Quaternary Structure

The arrangement of two or more folded polypeptide chains into a functional protein complex.

Unit Dimensionless

In depth

The subunits are held together by the same non-covalent forces that stabilise tertiary structure. Multi-subunit proteins can show cooperativity, in which binding at one site alters the affinity of the others — a form of regulation impossible for a single chain.

Examples in the real world

Haemoglobin's four subunits binding oxygen cooperatively to give its sigmoidal saturation curve.