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Organic Chemistry

Electrophilic Substitution

A reaction in which an electrophile replaces a hydrogen atom on an aromatic ring.

Formula / equation ArH + E⁺ → ArE + H⁺
Unit Dimensionless

In depth

The ring attacks the electrophile to form a resonance-stabilised carbocation, which then loses a proton to restore aromaticity. Substituents already on the ring direct the incoming group: electron donors send it ortho and para, electron withdrawers send it meta.

Examples in the real world

Nitration of benzene with a nitric and sulfuric acid mixture; Friedel–Crafts alkylation and acylation.