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Biochemistry & Polymer Chemistry

Glycosidic Bond

The covalent linkage joining a sugar unit to another molecule through an oxygen bridge.

Formula / equation C–O–C
Unit Dimensionless

In depth

It forms by condensation between the anomeric hydroxyl of one sugar and a hydroxyl of another, releasing water. Whether the linkage is alpha or beta, and which carbons it joins, determines both the three-dimensional shape of the polymer and which enzymes can cleave it.

Examples in the real world

The alpha-1,4 bonds of starch, digestible by amylase, against the beta-1,4 bonds of cellulose, which are not.