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Chemical Equilibrium

Association Constant

The equilibrium constant for the combination of two species into a single associated entity, the reciprocal of the dissociation constant.

Formula / equation Ka = 1 / Kd
Unit L/mol

In depth

Association constants are the natural way to express binding strength, with larger values meaning tighter binding. They are used throughout supramolecular chemistry and biochemistry, where they quantify how strongly a host binds a guest or an antibody binds its antigen.

Examples in the real world

The biotin–streptavidin pair has an association constant near 10¹⁵ L/mol, among the strongest known.