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Chemical Kinetics & Catalysis

Active Site

The specific region of a catalyst or enzyme at which the reacting molecules bind and are transformed.

Unit Dimensionless

In depth

On a solid catalyst active sites are typically steps, kinks and defects where surface atoms have unsatisfied bonding capacity. In enzymes the active site is a precisely shaped pocket that binds the substrate, strains it towards the transition state and often supplies acidic or basic groups.

Examples in the real world

The zinc-containing pocket of carbonic anhydrase; the under-coordinated edge atoms of a platinum nanoparticle.