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Biophysics & Medical Physics

Membrane Potential

The electrical potential difference across a biological cell membrane produced by asymmetric ion concentration gradients.

Governing formula V_m = V_in - V_out (Resting Potential ≈ -70 mV)
SI unit mV (Millivolts)

In depth

Maintained by active ATP-driven Na⁺/K⁺ pumps and selective potassium leak channels. Inside the cell is electrically negative (~-70 mV) relative to extracellular fluid, creating an electrochemical driving force for ion transport and cell signaling.

Examples in the real world

Resting membrane potential of -70 mV across giant squid axon cell membranes.